Lipid activation of protein kinase C.

Lipid activation of protein kinase C.

Activation of Protein Kinase C

The activation of protein kinase C by biologically active lipid moieties of lipopolysaccharide.

The monosaccharide lipid A precursor, N2,O3-diacylglucosamine 1-phosphate (Escherichia coli lipid X), has been shown previously to be a potent B-lymphocyte mitogen. We now report that lipid X interacts with macrophages, stimulating turnover of phosphatidylinositol, deacylation of phospholipids, and release of arachidonic acid. In addition, the monosaccharide lipid X, the incomplete lipid A disa...

Benzene-mediated protein kinase C activation.

Extracellular ligands transfer information into the cell through several pathways that operate in an integrated fashion. Protein kinase C, and enzyme that plays a pivotal role in signal transduction, is the molecular target for tumor promoters from the series of phorbol esters. A number of structurally unrelated tumor promoters also enhance protein kinase C, interacting or not interacting with ...

Pathway Involving Protein Kinase C Activation

Lysophosphatidylcholine (lysoPC) transferred from oxidatively modified low density lipoprotein (OxLDL) to the endothelial surface membrane has been shown to produce a selective unresponsiveness to cell surface receptor-regulated endothelium-dependent relaxation (EDR) in the rabbit aorta. To determine its mechanism we examined the effects of lysoPC on endothelial surface receptor-mediated transm...